Operating in modern-day London, the Hellsing Organization is dedicated of ridding England of the scourge of vampires. However, the principle weapon of this organization just happens to be a vampire himself - Alucard, who serves the organization's young leader, the iron-willed woman Sir Integra Wingates Hellsing, as well as Alucard's new apprentice, a young vampire woman named Seras Victoria

Lately, a rash of artificially-created vampires has taken the organization by surprise. As it turns out, a neo-Nazi society known as the Millennium Order is responsible for creating these vampires. Their sole purpose... to achieve what Nazi Germany couldn't do over 60 years ago with human soldiers... the total conquest of the world!